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Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

delete2016-01-01
delete40
PRE
AI
M
Morteza Hasanzadeh Kafshgari
B
Bahman Delalat
F
Frances J. Harding
A
Alex Cavallaro
E
Ermei Mäkilä
J
Jarno Salonen
K
Krasimir Vasilev
N
Nicolas H. Voelcker *
DOI：10.1039/c5tb02551fdelete
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Abstract

Abstract

En 中文
In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.
Keywords:
ANTIBIOTIC-RESISTANCE
WOUND CARE
EFFICACY
BACTERIA
SILVER

Journal

Journal of Materials Chemistry B cover
Journal of Materials Chemistry B
IF:
5.7
Papers:
1.1W
Citations:
4.3W

Organization

U
University of Turku
Scholars:
1.7W
Papers: 1.5W
Citations: 2.0W
U
University of South Australia
Scholars:
9.0K
Papers: 1.1W
Citations: 1.6W