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Antigen processing by the proteasome
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DOI：10.1038/35056572.png)
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Abstract
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The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes - the waste-disposal units of the cell - typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?.
Keywords:
MHC CLASS-I
NEWLY SYNTHESIZED PROTEINS
20S PROTEASOME
INTERFERON-GAMMA
CTL EPITOPE
MULTICATALYTIC PROTEINASE
RAPID DEGRADATION
BETA-SUBUNITS
ACTIVE-SITE
PEPTIDE
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