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Antigen Uptake in the Gut: An Underappreciated Piece to the Puzzle?
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DOI：10.1146/annurev-immunol-082523-090154.png)
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Abstract
En 中文
The mammalian gut is a vast, diverse, and dynamic single-layer epithelial surface exposed to trillions of microbes, microbial products, and the diet. Underlying this epithelium lies the largest collection of immune cells in the body; these cells encounter luminal substances to generate antigenspecific immune responses characterized by tolerance at homeostasis and inflammation during enteric infections. How the outcomes of antigenspecific tolerance and inflammation are appropriately balanced is a central question in mucosal immunology. Furthermore, how substances large enough to generate antigen-specific responses cross the epithelium and encounter the immune system in homeostasis and during inflammation remains largely unexplored. Here we discuss the challenges presented to the gut immune system, the identified pathways by which luminal substances cross the epithelium, and insights suggesting that the pathways used by substances to cross the epithelium affect the ensuing immune response.
Keywords:
intestine
antigen
microfold cell
transepithelial dendrite
paracellular
transport
goblet cell
Journal
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33.3
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775
Citations:
2.0W
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