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Antimicrobial Resistance and Virulence in Polymicrobial Chronic Wound Infections: A Metagenomic Perspective
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DOI：10.1016/j.jiph.2026.103280.png)
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Abstract
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• Shotgun metagenomics revealed highly diverse polymicrobial communities in chronic wound infections • Clinically important antimicrobial resistance genes were widespread across wound microbiomes • Virulence determinants associated with biofilm formation and persistence were frequently detected • Metagenomic analysis uncovered resistance and virulence features missed by culture-based methods • Findings highlight significant implications for infection control and antimicrobial stewardship
Keywords:
Antimicrobial resistance
Genomic analysis
Antibiotic resistance genes
Chronic wound infections
Public health interventions
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