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Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain
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DOI：10.1002/epi.70412.png)
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Abstract
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Based on the evidence that fenfluramine-induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d-enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat maximal electroshock seizure (MES) test. This is part of a series of studies aimed at optimizing selection of an enantiomerically pure compound for development as a safer alternative to racemic fenfluramine.
Keywords:
concentration–response relationships
enantiomers
fenfluramine
MES model
MMI model
rats
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