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APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update

delete2026-06-27
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PRE
AI
H
Hong You
R
Rakhi Maiwall
J
Jing Chen
S
Sang Hoon Ahn
K
Kadir Dokmeci
M
Manal El-Sayed
J
Jian-Gao Fan
R
Rino Gani
Z
Zhiliang Gao
H
Hasmik Ghazinian
G
George Goh
S
Saeed Hamid
J
Jinlin Hou
S
Shang-Chin Huang
D
Dong Ji
J
Jidong Jia
T
Tatsuo Kanda
J
Jia-Horng Kao
Y
Yoon Jun Kim
C
Cosmas Rinaldi A. Lesmana
R
Rosmawati Mohamed
Q
Qin Ning
N
Necati Örmeci
M
Motoyuki Otsuka
D
Diana Payawal
P
Pham Thanh Thuy
K
Keo Sailey
M
Manoj Kumar Sharma
J
Jose D. Sollano
J
Jian Sun
T
Tawesak Tanwandee
A
Alexander Thompson
F
Fu-Sheng Wang
G
Guiqiang Wang
L
Lai Wei
G
Grace Lai Hung Wong
V
Vincent Wai Sun Wong
E
Eng Kiong Yeoh
T
Terry Cheuk-Fung Yip
M
Ming-Lung Yu
W
Wenhong Zhang
H
Hui Zhuang
C
Ching-Lung Lai
M
Masao Omata
S
Shiv Kumar Sarin
G
George Lau
DOI:10.1007/s12072-026-11108-1delete
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Abstract

Abstract

En 中文
Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis, and hepatocellular carcinoma. This has happened despite the past four decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies, and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, these clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy-makers, and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in 13 major areas related to screening, vaccination, treatment, and HCC surveillance. The implementation of these clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia Pacific region.
Keywords:
Chronic hepatitis B
Prevention
Treatment
Hepatocellular carcinoma
Treat all
Guideline
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Hepatology International cover
Hepatology International
IF:
6.1
Papers:
2.1K
Citations:
5.9K

Organization

I
Institute of Gastroenterology
Scholars:
24
Papers: 15
Citations: 0
H
Humanity and Health Clinical Trial Center
Scholars:
3
Papers: 4
Citations: 0
L
liver research institute
Scholars:
2
Papers: 3
Citations: 0
F
fifth medical center of chinese
Scholars:
2
Papers: 1
Citations: 0
D
department of gastroenterology & hepatology
Scholars:
13
Papers: 5
Citations: 0
U
Uonuma Institute of Community Medicine
Scholars:
5
Papers: 7
Citations: 0
N
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Papers: 8.2K
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D
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Citations: 1
H
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S
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3
Papers: 1
Citations: 0
W
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Papers: 2.3K
Citations: 5.7K
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Papers: 82
Citations: 1.7W
Siriraj Hospital cover
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Citations: 3.3K
N
nanfang hospital
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Papers: 177
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Papers: 50
Citations: 53
T
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Papers: 2.8K
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C
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Papers: 5
Citations: 0
H
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Papers: 5
Citations: 0
Y
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Scholars:
2
Papers: 1
Citations: 0
F
Faculty of Medicine and Surgery
Scholars:
89
Papers: 53
Citations: 0
S
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Papers: 6
Citations: 0
B
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Citations: 0
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D
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X
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Papers: 5
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H
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Citations: 0
C
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Papers: 5
Citations: 0
Y
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3
Papers: 3
Citations: 0
D
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Scholars:
6
Papers: 3
Citations: 0
I
institute of liver and biliary sciences
Scholars:
62
Papers: 21
Citations: 0
L
Liver Transplantation Center
Scholars:
11
Papers: 6
Citations: 0
K
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Scholars:
331
Papers: 192
Citations: 14
A
aga khan university
Scholars:
1.3K
Papers: 402
Citations: 0
D
department of gastroenterology and hepatology
Scholars:
174
Papers: 56
Citations: 0
F
faculty of medicine
Scholars:
6.0K
Papers: 2.1K
Citations: 0
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