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Application of Shear Stress-Based Scale-Down Approaches for Crystallizer Design and Optimization
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DOI：10.1016/j.cherd.2026.06.060.png)
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Abstract
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● The complex hydrodynamic environment of a plant-scale crystallizer was quantitatively analyzed using Computational Fluid Dynamics (CFD). ● Volume-averaged shear stress, which directly influences the physical properties of crystals, was identified as a key parameter and proposed as the criterion for laboratory scale-down. ● A shear stress environment similar to that of the plant was successfully reproduced in the 60 L pilot-scale crystallizer through structural modifications (baffles, dual impellers, high-shear mixer (HSM)) and the optimization of agitation conditions. ● The consistency of the scale-down approach was confirmed through CFD modeling and simulation.
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