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Applications of typical macrocyclic hosts in inclusion technology across multiple fields
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DOI：10.1007/s13738-026-03384-3.png)
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Abstract
En 中文
This paper systematically reviews the latest progress of inclusion technology as a key branch of supramolecular chemistry. Firstly, it elaborates on its theoretical basis based on molecular recognition and non-covalent interactions, as well as thermodynamic and kinetic principles. Subsequently, it detailedly analyzes the structural characteristics, inclusion behaviors and performance comparisons of five typical macrocyclic host molecules: cyclodextrins, calixarenes, cucurbiturils, crown ethers, and pillararenes. Unlike previous reviews that usually focus on a single category of macrocyclic molecules or a narrow application field, this work innovatively achieves a cross-domain integration of their structural-property relationships and practical applications across pharmaceuticals, pesticides, and veterinary drugs, while also linking basic theoretical research with cutting-edge industrial demands. Focusing on the application scenarios of pharmaceuticals, pesticides, and veterinary drugs, it emphasizes the extensive application examples and research frontiers of inclusion technology in fields such as drug delivery, monitoring, environmental science, and materials science. Finally, the current challenges faced by this technology are analyzed, and its future development directions in intelligent materials, precision medicine, and sustainable development are prospected.
Keywords:
Inclusion technology
Controlled-release
Complexation
Bioavailability
Biosafety
Journal
IF:
2.3
Papers:
138
Citations:
5.0K
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