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Applying Genetic Algorithm with Saltations to MAX-3SAT

delete2026-01-01
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PRE
AI
R
Ryan Alomair *
H
Hafsa Farooq
S
Seth Sims
A
Akshay Juyal
Z
Zelikovsky, Alexander
DOI:10.1007/978-3-032-02489-3_19delete
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Abstract

Abstract

En 中文
Punctuated equilibrium, the pattern of rapid, significant mutational change, had not been observed in real time until the SARS-CoV-2 viral variants emerged with multiple mutations occurring together. Using epistasis (the circumstance in which the effect of one gene is influenced by the presence of one or more other genes) as a framework to understand this phenomenon, we can capture the relationships between different combinations of mutations, where each node is an individual mutation, and each edge represents the interaction between them, allowing us to effectively model the fitness landscape of viral variants. In exploring these relationships, it has been found that dense subgraphs within the network correspond to emerge saltation. We refer to this as an evolutionary jump and incorporate it with a genetic algorithm (GA + EJ), which can uncover high-fitness regions seemingly distant from the variant(s) from which they originally derived. We applied it to the MAX-3SAT problem and found improvement for satisfiable problem instances with 600 variables and 2550 clauses, as well as 100 variables and 429 clauses.
Keywords:
MAX-3SAT Problem
Evolution
Genetic Algorithm
Epistatic network

Journal

C
COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES, ICCABS 2025
IF:
0
Papers:
23
Citations:
0

Organization

U
university system of georgia
Scholars:
7.3W
Papers: 6.5W
Citations: 101