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Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic
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DOI：10.1038/s44318-025-00450-z.png)
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Abstract
En 中文
Metabolic reprogramming in cancer cells is complex. Cancer cells rewire nutrient uptake and enzyme activity to support malignant properties. These metabolic phenotypes are the combination of intrinsic factors, including mutation status or tissue of origin, and extrinsic factors, such as alterations in blood supply or the contributions of multiple cell types within the tumor microenvironment. This complexity can be challenging to reproduce in vitro and has prompted investigators to study tumor metabolism in vivo, including directly in patients. By administering nutrients labeled with a stable isotope to patients, investigators can track labeled atoms through biochemical reactions, providing a detailed assessment of tumor metabolism. In this perspective, we discuss stable isotope tracing in cancer patients from the perspective of protocol initiation, the workflows and pitfalls in establishing these procedures, and offer insights into analyzing tumor metabolism from patient samples.
Keywords:
Intraoperative Patient Infusions
Stable Isotope Tracing
Cancer Metabolism
Journal
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8.3
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1.3W
Citations:
6.3W
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Cited Papers