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Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism

delete2026-07-20
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PRE
AI
H
Hui Zhang *
L
Lele Ma
S
Shaoju Gan
M
Mengyuan Jiang
Z
Zheng Zhang
W
Weidi Sun
W
Wanlin Xie
P
Peiyu Xi
F
Fengli Qu *
谭蔚泓 cover
谭蔚泓 (Weihong Tan)
DOI：10.1016/j.chembiol.2026.06.011delete
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Abstract

Abstract

En 中文
• A high-affinity DNA aptamer targets the proinflammatory B-box of HMGB1 • Extracellular HMGB1 is neutralized, suppressing inflammatory signaling • Organ injury is reduced in endotoxemia, and survival improves in polymicrobial sepsis • Methotrexate efficacy is enhanced in chronic inflammatory arthritis

Journal

Cell Chemical Biology cover
Cell Chemical Biology
IF:
7.2
Papers:
1.7K
Citations:
9.1K

Organization

U
UCAS
Scholars:
97
Papers: 57
Citations: 4
C
chinese academy of sciences
Scholars:
55.3W
Papers: 44.6W
Citations: 704
U
University of Science and Technology of China
Scholars:
1.5W
Papers: 5.4K
Citations: 11.3W
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