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Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
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DOI：10.3390/s131013624.png)
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Abstract
En 中文
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
Keywords:
aptamer
SELEX
cancer
diagnostics
locked nucleic acid
unlocked nucleic acid
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