Antibacterial and Immunomodulatory Effects of Limosilactobacillus reuteri LMG P-27481 and Resveratrol Relevant for the Control of Upper Respiratory Tract Pathobionts

Roberto Mattioli

doi:10.3390/microorganisms14081771

Aquaporin-1 gene therapy as a novel method to treat radiation-induced salivary gland damage: The case for adeno-associated virus vectors

2026-07-03

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AI

N

Natalie Atyeo *

B

Blake M. Warner

J

John A. Chiorini

DOI：10.1016/j.oraloncology.2026.108071

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Abstract

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• Ionizing radiation for head and neck cancer damages surrounding structures. • Salivary gland damage lead to hyposalivation and chronic dry mouth. • Insertion of aquaporin-1 (AQP1) in the gland epithelium is a promising therapy. • Adenoviruses have successfully been used to deliver AQP1 to human salivary glands. • Adeno-associated viruses are a less immunogenic option for gene delivery.

Aquaporin-1 gene therapy as a novel method to treat radiation-induced salivary gland damage: The case for adeno-associated virus vectors

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