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Armed oncolytic adenovirus elicits a “self-feeder” effect to supercharge NK cells for solid tumor control
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DOI：10.1016/j.cellimm.2026.105100.png)
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Abstract
En 中文
• Establishes novel “self-feeder” effect via armed oncolytic adenovirus (oAds) for sustained NK activity. • Dual-phase strategy synergizes ex vivo NK expansion with in situ oAds activation. • oAd-IL-2/mbIL-21/4–1BBL and NK cells synergistically enhance solid tumor control.
Keywords:
oAd-IL-2/mbIL-21/4–1BBL
NK cells
solid tumor control
self-feeder effect
oncolytic adenovirus
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