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Aromatic halogenation using carborane catalyst
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DOI：10.1016/j.chempr.2023.10.006.png)
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Abstract
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Haloarenes have been an important class of chemicals in the modern organic chemistry field because the halide functionality offers numerous possible transformations. Classical electrophilic aromatic halogenation using molecular halogens and Lewis/Bronsted acid activators is still a promising synthetic tool; however, it suffers from handling difficulties, low selectivity, and limited functional group tolerance. We herein introduce carborane-based Lewis base catalysts for aromatic halogenation using N-halosuccinimides. The developed reaction system was readily applicable to the late -stage functionalization of drug molecules and the efficient synthesis of multi -halogenated aromatics. The m-carborane scaffold was most suitable for catalysis, and the possible fine-tuning by decorating the cluster vertices was important for modulating the electronic property of halonium species to maximize the catalytic performance.
Keywords:
CHEMISTRY
BROMINATION
ARENES
ACID
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