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Array-based sensing of proteins using conjugated polymers

delete2007-07-21
delete276
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OA
AI
O
Oscar R. Miranda
C
Chang‐Cheng You
R
Ronnie L. Phillips
I
Ik‐Bum Kim
P
P. S. Ghosh
U
Uwe H. F. Bunz *
V
Vincent M. Rotello
DOI：10.1021/ja0737927delete
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Abstract

Abstract

En 中文
A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
Keywords:
CARBOXYLATE-SUBSTITUTED PPE
SENSOR ARRAY
NONSPECIFIC INTERACTIONS
AMINO-ACIDS
RECOGNITION
IDENTIFICATION
FLUORESCENCE
RECEPTORS
PATTERNS

Journal

Journal of the American Chemical Society cover
Journal of the American Chemical Society
IF:
15.6
Papers:
20.0W
Citations:
60.2W

Organization

No organization information available