Arsenic-responsive hsa_circ_0000118 couples early stress granule dynamics to later NF-κB-related signaling adaptation in NSCLC

Jingwen Tan

doi:10.1016/j.jhazmat.2026.143203

Arsenic-responsive hsa_circ_0000118 couples early stress granule dynamics to later NF-κB-related signaling adaptation in NSCLC

2026-08-08

0

PRE

AI

J

Jingwen Tan

刘

刘娜 (Na Liu)

张元 (Yuan Zhang)

J

Jingchao Yang

X

Xuefei Yang

X

Xinda Yang

B

Bin Chen

Y

Yuefeng He *

DOI：10.1016/j.jhazmat.2026.143203

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• hsa_circ_0000118 is elevated in arsenic-exposed subjects and NSCLC cells. • Its depletion is associated with increased SG accumulation and persistence. • QKI associates with hsa_circ_0000118 and G3BP1-containing complexes. • hsa_circ_0000118 depletion impairs NF-κB-related adaptive output. • hsa_circ_0000118 is associated with acute and sustained arsenic responses.

Arsenic-responsive hsa_circ_0000118 couples early stress granule dynamics to later NF-κB-related signaling adaptation in NSCLC

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