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Artificial protein scaffolds for human therapeutics: drug discovery and delivery strategies
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DOI：10.1016/j.drudis.2026.104689.png)
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Abstract
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• Artificial protein scaffolds offer superior stability, modularity and deep-tissue penetration for next-generation therapeutics. • Artificial protein scaffolds enable targeting of undruggable protein–protein interactions using engineered high-affinity surfaces. • Advances in AI and machine learning can accelerate artificial protein scaffold design, specificity and developability. • Clinical translation is progressing with DARPins, affibodies, anticalins in oncology and immunotherapy trials.
Keywords:
Artificial protein scaffolds
drug discovery
precision therapeutics
protein engineering
targeted drug delivery
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