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Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification
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DOI：10.1016/j.matbio.2026.03.005.png)
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Abstract
En 中文
• XRF imaging showed that proteoglycan sulfation decreases during cartilage maturation • ARSI is expressed where cartilage sulfation decreases • Biochemical analyses show that ARSI is a novel endosulfatase of chondroitin-4-sulfate at acidic pH • ARSI localizes to lysosomes, which are disrupted in Arsi-/- chondrocytes • Maturation markers are upregulated in Arsi-/- chondrocytes
Keywords:
endochondral ossification
cartilage maturation
chondroitin sulfate proteoglycans
XRF imaging
endosulfatase
ARSI
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