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Assembling the pieces

delete2008-03-01
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D
Dennis J. Thiele *
J
Jonathan D. Gitlin
DOI:10.1038/nchembio0308-145delete
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Abstract

Abstract

En 中文
Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.
Keywords:
RAY-FLUORESCENCE MICROSCOPY
COPPER
IRON
METABOLISM
HOMEOSTASIS
TOPOGRAPHY
EVOLUTION
VIRULENCE
NUTRIENT
ELEMENTS
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Nature Chemical Biology cover
Nature Chemical Biology
IF:
13.7
Papers:
4.8K
Citations:
3.3W

Organization

D
Duke University
Scholars:
6.3W
Papers: 5.7W
Citations: 6.5W
W
washington university (wustl)
Scholars:
5.5W
Papers: 4.5W
Citations: 70
Cited Papers

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