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Assessing the Effects of a 3D Pathology Tissue-Processing Workflow on Downstream Molecular Analyses
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DOI：10.1016/j.labinv.2026.106147.png)
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Abstract
En 中文
Non-destructive 3D pathology methods have emerged in recent years with the potential to enhance standard 2D histopathology by greatly increasing the amount of tissue sampled by imaging and by providing volumetric morphological context. Another key advantage is that tissues remain intact, allowing re-embedding after imaging for potential long-term storage and future histological or molecular analyses. Here, we aim to systematically evaluate the impact of 3D pathology protocols on biomolecules — including DNA, RNA, and proteins — and their compatibility with downstream assays.
Keywords:
3D pathology
tissue processing
molecular integrity
open-top light-sheet (OTLS) microscopy
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