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Assessment and validation of the established free-running framework for cardiac function by magnetic resonance imaging at 1.5 T (FAST-CMR): an international multi-center, multi-vendor study
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DOI：10.1016/j.jocmr.2026.102784.png)
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Abstract
En 中文
Cardiovascular magnetic resonance (CMR) is the reference standard for assessing cardiac function, yet its widespread clinical use remains challenged by time-intensive workflows requiring ECG gating, repetitive breath-holding, and expert planning. The free-running framework (FRF) addresses these barriers by enabling respiratory and cardiac motion resolved (5D) whole-heart imaging without ECG, breath-holds, or expert scan plane planning. Its fast interrupted steady-state (FISS) variant further enables high quality clinical imaging with gadolinium-based or ferumoxytol contrast agents by providing balanced steady-state free precession (bSSFP)-like contrast with intrinsic fat suppression. The combined 5D FISS-FRF approach, therefore, enables 3D, motion-resolved, free-breathing whole-heart imaging with efficient fat suppression. Early single-center studies have demonstrated feasibility and high concordance with conventional 2D cine imaging, but its generalizability and clinical utility in a multi-center, multi-vendor setting is not yet established.
Keywords:
CMR
Cardiovascular magnetic resonance
EF
Ejection fraction
ECG
Electrocardiogram
2D
Two-dimensional
3D
Three-dimensional
AI
Artificial intelligence
FRF
Free-Running Framework
5D
Five-dimensional
bSSFP
Balanced steady-state free precession
LIBRE
Lipid insensitive binomial off-resonant RF excitation
FISS
Fast-interrupted steady-state
LIBOR
Lipid insensitive binomial off-resonant
LV
Left ventricle
LVEF
Left ventricular ejection fraction
CHD
Congenital heart disease
MRI
Magnetic resonance imaging
CHUV
Lausanne University Hospital
COPD
Chronic obstructive pulmonary disease
QA
Quality assurance
WIP
Works-In-Progress
TR
repetition time
TE
echo time
EDV
End-diastolic volume
ESV
End-systolic volume
AHA
American Heart Association
SCMR
Society of Cardiovascular Magnetic Resonance
RV
Right ventricle
SSIM
Structural similarity index measure
PSNR
Peak signal-to-noise ratio
RMSE
Root mean-squared error
ICC
Intraclass correlation coefficient
CoV
Coefficient of Variation
FDR
False discovery rate
Free-running
Cine magnetic resonance imaging
Ventricular function
Multi-center
Multi-vendor
FISS (Fast- Interrupted Steady-State)
Compressed sensing
Pragmatic clinical study
Journal
IF:
6.1
Papers:
2.3K
Citations:
6.9K
Organization
Cited Papers