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Association between healthy lifestyle score and thyroid function biomarkers in adults: a cross-sectional analysis
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DOI：10.1017/S0007114526106382.png)
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Abstract
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The current study was designed to examine the association between a composite healthy lifestyle score (HLS) and thyroid function biomarkers among American adults. This cross-sectional study utilised data from 5693 adults aged ≥ 18 years in the National Health and Nutrition Examination Survey 2007–2012 cycles. A HLS (range 0–6) was constructed based on six modifiable factors: non-smoking; no heavy alcohol intake; normal BMI (18·5–24·9 kg/m2); high physical activity (upper tertile of metabolic equivalent-min/week); adequate sleep (7–9 h/night) and appropriate energy intake. Serum concentrations of thyroid-stimulating hormone; free and total thyroxine (FT4; TT4); free and total triiodothyronine (FT3; TT3); thyroglobulin (Tg) and thyroid antibodies (TPOAb; TgAb) were measured. Multivariable linear regression adjusted for sociodemographic factors was used to assess associations. In fully adjusted models; each one-point increase in HLS was associated with lower serum FT4 (β = –0·07 ng/dl; 95 % CI: –0·10; –0·03; P < 0·001) and TT4 (β = –0·11 µg/dl; 95 % CI: –0·15; –0·06; P < 0·001). Compared with participants with an HLS of 0–1; those with HLS 4–6 had lower FT4 (β = –0·20; 95 % CI: –0·30; –0·09; P < 0·001) and TT4 (β = –0·36; 95 % CI: –0·49; –0·22; P < 0·001). Associations for other thyroid markers were not statistically significant after correction for multiple comparisons (P > 0·05). A healthier lifestyle is inversely associated with serum FT4 and TT4 levels; highlighting potential links between modifiable behaviours and thyroid physiology.
Keywords:
Thyroid function tests
Lifestyle
Cross-sectional studies
National Health and Nutrition Examination Survey
Adult
Free Triiodothyronine
Free Thyroxine
Healthy Lifestyle Score
National Health and Nutrition Examination Survey
Thyroglobulin
Thyroglobulin Antibody
Thyroid Peroxidase Antibody
Thyroid-Stimulating Hormone
Thyroxine
Triiodothyronine
Total Thyroxine
Total Triiodothyronine
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