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Association between primary sclerosing cholangitis and stroke: a Mendelian randomization study

delete2025-12-31
delete0
PRE
AI
J
Jun Liu
Y
Yunguo Zhao
J
Jingmei Wang
Y
Yiping Wu *
Z
Zhongbo Zhang
H
Haibo Wang
H
Haili Zhang
DOI：10.1080/14796708.2025.2574250delete
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Abstract

Abstract

En 中文
ObjectiveThe causal relationship between primary sclerosing cholangitis (PSC) and stroke risk remains unclear. We attempt to explore the causal relationship between PSC and stroke risk.MethodsA two-sample Mendelian randomization (MR) study was performed based on the genome-wide association study (GWAS) data to analyze the causal effect of PSC on the risk of stroke. The inverse-variance weighted (IVW), MR-Egger regression and weighted median were used for analysis.ResultsEighteen single-nucleotide polymorphisms (SNPs) associated with PSC were selected from GWASs as instrumental variables (IVs). The results of IVW methods showed that PSC was associated with a higher risk of stroke (beta = 0.0006, standard error [SE] = 0.0002, P = 0.017). Similarly, the results of MR-Egger methods showed consistent results (beta = 0.0008, SE = 0.0004, P = 0.045). Likewise, the association between PSC and stroke has been confirmed, using the weighted median methods (beta = 0.0009, SE = 0.0003, P = 0.006). The consistent results revealed a causal relationship between PSC and increased stroke risk. Cochran's Q test was used and low heterogeneity was identified (IVW. Q = 18.4, P = 0.364; MR-Egger. Q = 17.65, P = 0.345).ConclusionThe study results revealed that PSC might be causally associated with an increased risk of stroke.
Keywords:
Stroke
primary sclerosing cholangitis
Mendelian randomization

Journal

F
Future Neurology
IF:
0.5
Papers:
15
Citations:
0

Organization

No organization information available