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ASSOCIATION BETWEEN TP-E INTERVAL PROLONGATION AND MYOCARDIAL INJURY IN GASTROINTESTINAL BLEEDING
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DOI：10.18087/cardio.2026.3.n3024.png)
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Abstract
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Aim This study aimed to evaluate ventricular arrhythmia risk among patients who developed myocardial injury due to gastrointestinal bleeding by using the Tp-e interval, a predictive marker of ventricular arrhythmia. It is known that myocardial injury may develop secondary to gastrointestinal bleeding. This condition has been linked to an elevated risk of cardiac arrhythmia, a condition for which the Tp-e interval on electrocardiography is a marker. Material and methods The study included patients who presented to the emergency department with subsequently confirmed gastrointestinal bleeding. Based on high-sensitivity troponin T (hs-TnT) concentrations at presentation, two groups were formed: Patients with myocardial injury (hs-TnT >14 ng / l) and those without injury (hs-TnT <= 14 ng / l). Ventricular repolarization markers were measured to explore the association between these parameters and myocardial injury. Results Among cases of gastrointestinal bleeding, those presenting with myocardial injury exhibited significantly elevated Tp-e interval (73.5 +/- 9.1 vs. 62.1 +/- 6.8 msec, p<0.001) and Tp-e / QTc (0.16 +/- 0.02 vs. 0.13 +/- 0.07, p<0.001) values compared to those without myocardial injury. Myocardial injury correlated positively with the Tp-e interval and Tp-e / QTc (r=0.577 and r=0.528, respectively; p<0.001 for each). Conclusion In cases of gastrointestinal bleeding, myocardial injury was positively correlated with prolonged Tp-e interval and increased Tp-e / QTc, parameters associated with elevated risk of ventricular arrhythmia. The clinical significance of this association remains uncertain and requires confirmation and further assessment in future studies.
Keywords:
Gastrointestinal bleeding
myocardial injury
Tp-e interval
Tp-e /QTc
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