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Association of prompt phenotype-desirable antimicrobial therapy with short-term mortality and hospital-onset Clostridioides difficile infection among adults with community-onset bacteraemia
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DOI：10.1016/j.jgar.2026.05.004.png)
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Abstract
En 中文
• Prompt PDAT was associated with lower 30-day mortality in adults with bacteraemia. • Earlier PDAT was also associated with a lower risk of hospital-onset C. difficile infection. • These associations were consistent across clinically relevant subgroups. • Early transition to PDAT may support antimicrobial stewardship in bacteraemia care.
Keywords:
phenotype-desirable antimicrobial therapy
community
bloodstream infection
Clostridioides difficile infection
mortality
AHR
adjusted hazard ratio
CDI
Clostridioides difficile infection
CLSI
Clinical and Laboratory Standards Institute
DOOR-MAT
Desirability of Outcome Ranking for the Management of Antimicrobial Therapy
ED
emergency department
hCDI
hospital-onset CDI, ID, infectious disease
PBS
Pitt bacteraemia score
PDAT
phenotype-desirable antimicrobial therapy
Q1
first quartile
Q3
third quartile
SSC
Surviving Sepsis Campaign
STROBE
Strengthening the Reporting of Observational Studies in Epidemiology
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