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Associations of <i>Helicobacter pylori</i> infection with NAFLD, MAFLD, MASLD, and Chinese MAFLD
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DOI：10.1177/17562848261465720.png)
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Abstract
En 中文
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>
The association of
<jats:italic toggle="yes">Helicobacter pylori</jats:italic>
(
<jats:italic toggle="yes">H. pylori</jats:italic>
) infection with non-alcoholic fatty liver disease (NAFLD) remains controversial. Additionally, its associations with metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and Chinese MAFLD using the most recent diagnostic criteria were unclear.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Objective:</jats:title>
<jats:p>
To analyze the associations of
<jats:italic toggle="yes">H. pylori</jats:italic>
infection with NAFLD, MAFLD, MASLD, and Chinese MAFLD.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Design:</jats:title>
<jats:p>Cross-sectional study.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods:</jats:title>
<jats:p>
This study screened 1172 inpatients who underwent both
<jats:italic toggle="yes">H. pylori</jats:italic>
test and liver computed tomography or ultrasound examination between June 2020 and May 2024. Multivariate Logistic regression analyses were performed to evaluate the associations of
<jats:italic toggle="yes">H. pylori</jats:italic>
infection with the severity of hepatic steatosis and risk of hepatic fibrosis. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, hypertension, hyperlipidemia, body mass index (BMI), fasting plasma glucose (FPG), and high-sensitivity C-reactive protein (HsCRP) in NAFLD analyses; age, gender, drinking, hypertension, diabetes, hyperlipidemia, BMI, and HsCRP in MAFLD analyses; and gender, drinking, hypertension, hyperlipidemia, BMI, FPG, and HsCRP in MASLD and Chinese MAFLD analyses.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>
Overall, 875, 982, 869, and 869 patients were included in NAFLD, MAFLD, MASLD, and Chinese MAFLD analyses, respectively. In NAFLD, MAFLD, MASLD, and Chinese MAFLD analyses, 257, 302, 257, and 257 patients had
<jats:italic toggle="yes">H. pylori</jats:italic>
infection, respectively.
<jats:italic toggle="yes">H. pylori</jats:italic>
infection was independently associated with severe hepatic steatosis in NAFLD (aOR = 3.956; 95% CI = 1.171–13.359,
<jats:italic toggle="yes">p</jats:italic>
= 0.027), MAFLD (aOR = 3.730; 95% CI = 1.083–12.850,
<jats:italic toggle="yes">p</jats:italic>
= 0.037), and MASLD (aOR = 3.962; 95% CI = 1.158–13.557,
<jats:italic toggle="yes">p</jats:italic>
= 0.028) analyses, but not Chinese MAFLD analyses. However,
<jats:italic toggle="yes">H. pylori</jats:italic>
infection was not independently associated with the risk of hepatic fibrosis.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion:</jats:title>
<jats:p>
<jats:italic toggle="yes">H. pylori</jats:italic>
infection may increase the severity of NAFLD, MAFLD, and MASLD, but not the risk of liver fibrosis.
</jats:p>
</jats:sec>
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