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Astilbin ameliorates hyperuricemia-associated renal injury in geese with gut-linked kynurenic acid immunometabolic remodeling

delete2026-06-19
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PRE
AI
Y
Yu Yang
S
Shanshan Fei
L
Li Yang *
Q
Qi Zhang
M
Mengran Cui
G
Guangliang Shi *
DOI：10.1016/j.intimp.2026.117019delete
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Abstract

Abstract

En 中文
• ASB targets the gut-kidney immune axis to quench HUA-induced sterile inflammation. • ASB remodels gut microbiota and restores hepato-intestinal IDO2 expression. • Endogenous KYNA restoration suppresses IL-1β, TNF-α, and IFN-γ cascades. • KYNA blocks immune-driven TGF-β/Smad profibrotic signaling in renal cells. • The uricase-deficient goose model mirrors human HN immunopathology.

Journal

International Immunopharmacology cover
International Immunopharmacology
IF:
4.7
Papers:
1.6W
Citations:
4.1W

Organization

N
Northeast Agricultural University
Scholars:
1.6K
Papers: 360
Citations: 1.8W
S
state key laboratory for ecological restoration and ecosystem management
Scholars:
2
Papers: 1
Citations: 0
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