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Astragaloside IV is a potential natural neuroprotective agent for stroke: a review
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DOI：10.3389/fphar.2025.1718700.png)
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Abstract
En 中文
Stroke poses a severe threat to human health; with limited therapeutic options currently available. Astragaloside IV (AS-IV); a primary bioactive metabolite derived from Astragalus membranaceus; exhibits multifaceted pharmacological effects; including anti-inflammatory; anti-fibrotic; and antioxidative properties. This review systematically examines recent advances in AS-IV research for stroke treatment; detailing its sources; physicochemical characteristics; mechanisms of action; and therapeutic efficacy in both in vitro and in vivo models. We critically analyze the potential of AS-IV as an adjunctive therapy for stroke; addressing current research hotspots; challenges; and emerging strategies. Notably; AS-IV synergistically enhances neuroprotection when combined with other plant-derived metabolites. This work provides a theoretical foundation for further development of AS-IV in stroke management. In summary; AS-IV demonstrates significant promise as a natural neuroprotective agent worthy of continued exploration for adjuvant stroke therapy.
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