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Astrocyte-mediated angiogenesis in CNS diseases: mechanisms and therapeutic implications
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Y
L
J
DOI:10.1016/j.brainresbull.2026.111914.png)
Abstract
En 中文
• Astrocytes exhibit context-dependent dual roles in CNS angiogenesis. • Disease-associated astrocyte subsets replace the binary A1/A2 paradigm. • VEGF shows a temporal dichotomy: acute harmful, subacute beneficial. • Targeting astrocyte subsets offers new strategies for stroke and GBM. • Single-cell and spatial omics are key to translating astrocyte biology.
Keywords:
Astrocytes
Angiogenesis
Neurovascular unit
Ischemic stroke
Glioblastoma
Heterogeneity
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