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Astrocytic extracellular matrix proteins in ADHD: The role of thrombospondin − 1, Sparc, and Sparcl-1

delete2026-05-05
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PRE
AI
N
Nilüfer Yildiz Kismet *
S
Selen Sezen Gökçearslan
S
Serenay Elgün Ülkar
S
Sadettin Burak Açikel
DOI：10.1016/j.pnpbp.2026.111731delete
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Abstract

Abstract

En 中文
• Thrombospondin-1, Sparc, and Sparcl-1 were reduced in the ADHD group. • Reduced ECM proteins were linked to executive and social function deficits. • Findings suggest glia-mediated synaptic pathology in ADHD pathophysiology. • Astrocyte-derived ECM proteins may serve as novel targets for ADHD interventions.
Keywords:
Thrombospondin-1
Sparc
Sparcl-1
extracellular matrix proteins
ADHD

Journal

P
Progress in Neuro-Psychopharmacology and Biological Psychiatry
IF:
3.9
Papers:
6.6K
Citations:
1.4W

Organization

A
ankara university
Scholars:
2.3K
Papers: 1.1K
Citations: 0
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