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Asymmetrically modified nucleosomes expand the histone code
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DOI：10.1038/nsmb.2433.png)
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Abstract
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According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes. Now, a new study challenges this notion by demonstrating that asymmetric histone modifications exist on individual mononucleosomes in native chromatin and that symmetric and asymmetric modifications signal different biological outcomes, suggesting a radically expanded histone code.
Keywords:
DNA-REPLICATION
H3
METHYLATION
GENES
MARKS
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