.png){kind=icon}
Return
Atom Environment Kernels on Molecules
.png){kind=icon}
PRE
AI
DOI：10.1021/ci400403w.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The measurement of molecular similarity is an essential part of various machine learning tasks in chemical informatics. Graph kernels provide good similarity measures between molecules. Conventional graph kernels are based on counting common subgraphs of specific types in the molecular graphs. This approach has two primary limitations: (i) only exact subgraph matching is considered in the counting operation, and (ii) most of the subgraphs will be less relevant to a given task. In order to address the above-mentioned limitations, we propose a new graph kernel as an extension of the subtree kernel initially proposed by Ramon and Gartner (2003). The proposed kernel tolerates an inexact match between subgraphs by allowing matching between atoms with similar local environments. In addition, the proposed kernel provides a method to assign an importance weight to each subgraph according to the relevance to the task, which is predetermined by a statistical test. These extensions are evaluated for classification and regression tasks of predicting a wide range of pharmaceutical properties from molecular structures, with promising results.
Keywords:
GRAPH KERNELS
Journal
IF:
5.3
Papers:
9.1K
Citations:
4.0W
Organization
Cited Papers
ShareSaveShareSaveShareSavePeroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury.png)
PLoS ONE
OAAI
PLoS ONEIF0
OAAIShareSaveShareSaveShareSave
View more