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Atomic Force Microscopy in Lung Cancer: From Mechanobiology to Clinical Translation
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DOI：10.1039/D6AY00786D.png)
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Abstract
En 中文
Atomic force microscopy (AFM) enables the nanoscale investigation of cellular mechanics; morphology; and molecular interactions under conditions that closely mimic physiological environments. This review synthesizes AFM analytical methodologies relevant to lung cancer; evaluating their applications in cell mechanics; early diagnosis; drug screening; and personalized therapy. Notable analytical advancements include the validation of cell stiffness as a mechanobiological biomarker; the development of AFM-based liquid biopsies with improved efficiency in capturing circulating tumor cells; and the incorporation of artificial intelligence for automated classification. A critical analysis of technical limitations addresses issues such as standardization; throughput; and controversies in data interpretation; as well as regulatory challenges that hinder clinical translation. Emerging trends include in vivo AFM; the integration of multi-omics approaches; and mechanoadjuvant strategies.
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