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Attoliter-level droplets ordered array based on acoustic nanoscissors
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DOI：10.1039/D5LC00807G.png)
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Abstract
En 中文
In the field of nano-fluidics; the generation and manipulation of minuscule droplets with volumes ranging from attoliters (aL) to femtoliters (fL) represents a crucial frontier. Such ultrasmall droplets exhibit immense potential in single -molecule detection; targeted drug delivery; and fundamental research into nanoscale biochemical processes; owing to their unique physicochemical properties; such as low Reynolds number flow and interface-dominated mass transport. Furthermore; ordered liquid-patterned arrays hold promise for applications in optically tunable nano-lenses. However; generation and manipulation of attoliter-scale droplets have long posed significant challenges; particularly for open-interface operations like dispensing; merging; splitting; and patterning into arrays. This study introduces acoustic nano-scissors generated by lateral modes of high frequency bulk acoustic wave. The induced acoustofluidic effect in thin liquid films forms shear forces between the adjacent wave peak and wave valley; thereby successfully cutting the liquid into attoliter-scale droplets at an open interface. This approach could produce droplets with volumes more than three orders of magnitude smaller than existing acoustic solutions. Furthermore; the acoustic nano-scissors could generate ordered attoliter droplets array with specific patterns; with fast droplet splitting and merging controlled by switching on and off the device. This work provides a novel and flexible solution for various applications requiring attoliter droplet arrays on open interfaces.