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Automated detection of cerebral microbleeds on ex-vivo MRI scans of community-based older adults
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DOI:10.1016/j.neuroimage.2026.121986.png)
Abstract
En 中文
• A comprehensive automated detection method for cerebral microbleeds on ex-vivo MRI • Combines synthesis with self-supervised pretraining and confidence-aware learning • Addresses data scarcity and class imbalance • Detects 90% of CMBs at 15 false positives in data from community-based older adults • Partially automates CMB annotation enabling large-scale MRI and pathology studies
Keywords:
magnetic resonance imaging
neuropathology
microbleed
ex-vivo
biomarkers
CMB=cerebral microbleed
CAA=cerebral amyloid angiopathy
AD=Alzheimer’s disease
ICH=intracerebral hemorrhage
SWI=susceptibility weighted imaging
GRE=gradient echo
MAP=Rush Memory and Aging Project
MARS=Minority Aging Research Study
ROS=Religious Orders Study
PMI=post-mortem interval
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