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Autophagy and Protein Quality Control in Parkinson's Disease
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DOI：10.1101/cshperspect.a041619.png)
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Abstract
En 中文
Autophagy is a vital cellular process responsible for the degradation of proteins, organelles, and other cellular components within lysosomes. In neurons, basal autophagy is indispensable for maintaining cellular homeostasis and protein quality control. Accordingly, lysosomal dysfunction has been proposed to be associated with neurodegeneration, and with Parkinson's disease (PD) in particular. Aging, dopamine metabolism, and PD-linked genetic mutations are thought to impair the autophagic-lysosomal pathway, disrupt cellular proteostasis, and contribute to PD pathogenesis. These alterations represent an opportunity to identify potential new therapeutic targets and disease biomarkers, thus laying the groundwork for the development of novel disease-modifying strategies for PD that are aimed at restoring cellular proteostasis and quality control systems.
Keywords:
CHAPERONE-MEDIATED AUTOPHAGY
ALPHA-SYNUCLEIN ACCUMULATION
GENOME-WIDE ASSOCIATION
GAUCHER-DISEASE
LYSOSOMAL DEGRADATION
ER STRESS
MITOCHONDRIAL-FUNCTION
JUVENILE PARKINSONISM
THERAPEUTIC TARGET
MOUSE MODEL
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10.1
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1.3W
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