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AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs
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DOI：10.1016/j.devcel.2026.06.004.png)
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Abstract
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• AXIN1 and AXIN2 prevent precocious differentiation of pluripotent epiblast cells • Combinatory WNT/BMP/NODAL signaling governs specification of distinct mesoderm types • WNT/BMP direct posterior while WNT/NODAL direct anterior mesoderm identities • WNT signaling temporally and spatially restricts BMP signaling in the mouse embryo
Keywords:
Axin
WNT
BMP
NODAL
mouse embryo
pluripotency
gastrulation
mesoderm
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