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B2pin2-Assisted Nickel-Catalyzed Z-Selective Semi-Hydrogenation of Alkynes With Formic Acid
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DOI：10.1002/adsc.70588.png)
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Abstract
En 中文
A nickel-catalyzed, boron-aided system enables highly stereoselective semi-hydrogenation of alkynes to Z-alkenes, with formic acid employed as a benign hydrogen source to ensure operational safety. This protocol affords Z-alkenes in up to 95% yield and 96/4 stereoselectivity, displays excellent functional group tolerance, and gains further experimental validation via gram-scale synthesis and facile product isolation. Mechanistic investigations confirm a homogeneous reaction pathway, with B2pin2 facilitating the in situ generation of hydrogen from formic acid.
Keywords:
alkenes
alkynes
hydrogen transfer
ni catalysis
stereoselectivity
Journal
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4
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424
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