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Bacteroides acidifaciens Attenuates Concanavalin A–Induced Liver Injury by Remodeling Bile Acids to Suppress CD95-Mediated Hepatocyte Apoptosis via the Takeda G Protein-Coupled Receptor 5–FOSL1 Pathway
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DOI：10.1016/j.jcmgh.2026.101838.png)
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Abstract
En 中文
Liver diseases have profound impacts on human physiological health. Gut microbiota and their metabolites exert significant regulatory roles in various hepatic disorders. Intestinal Bacteroides acidifaciens has been proven to be protective for hepatocyte apoptosis in some liver disease models, such as concanavalin A–induced hepatitis and acute/chronic alcoholic liver diseases. However, the specific metabolites from B acidifaciens and their regulatory mechanisms need to be further elucidated.
Keywords:
Bacteroides acidifaciens
CD95
Glycocholic Acid
Hepatocyte
TGR5
β-MCA
β-muricholic acid
ALT
alanine aminotransferase
ANIT
α-naphthyl isothiocyanate
BA
Bacteroides acidifaciens
BSH
bile salt hydrolase
CA
cholic acid
CAR
constitutive androstane receptor
CDCA
chenodeoxycholic acid
ConA
concanavalin A
DBil
direct bilirubin
DCA
deoxycholic acid
FGF
fibroblast growth factor
FXR
farnesoid X receptor
GCA
glycocholic acid
GCDCA
glycochenodeoxycholic acid
GSH
glutathione
H&E
hematoxylin and eosin
HCA
hyocholic acid
HDCA
hyodeoxycholic acid
IHC
immunohistochemistry
KO
knockout
LC-MS
liquid chromatography–mass spectroscopy
MAFLD
metabolic-associated fatty liver disease
PBS
phosphate-buffered saline
PI3K
phosphoinositide 3-kinase
qRT-PCR
quantitative reverse-transcription polymerase chain reaction
S1PR2
sphingosine-1-phosphate receptor 2
TBil
total bilirubin
TCDCA
taurochenodeoxycholic acid
TDCA
taurodeoxycholic acid
TDHCA
taurodehydrocholic acid
TGR5
Takeda G protein-coupled receptor 5
THCA
taurohyocholic acid
THDCA
taurohyodeoxycholic acid
TLCA
taurolithocholic acid
TUDCA
tauroursodeoxycholic acid
TUNEL
terminal deoxynucleotidyl transferase dUTP nick end labeling
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