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Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro

delete2026-04-17
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H
Hiroki Machida
J
Jun Yokota
H
Hironobu Fujiwara *
DOI:10.1016/j.matbio.2026.102008delete
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Abstract

Abstract

En 中文
• Dermal papilla cells are embedded in a basement membrane-like ECM • Dermal papilla cells adhere to laminins with α1, α2 and α4 chains via integrin α7β1 • Matrigel promotes dermal papilla aggregate formation and preserves spheroid cohesion • Basement membrane-like ECM supports fibroblast aggregation
Keywords:
basement membrane
hair follicle
epithelial‒mesenchymal interaction
dermal papilla
laminin
integrin α7
ECM
extracellular matrix
DP
dermal papilla
HG
hair germ
Mx
hair matrix
BM
basement membrane
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Matrix Biology cover
Matrix Biology
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