Betulinic acid ameliorates cavernous nerve injury-induced erectile dysfunction through Nrf2/HO-1 pathway activation and inhibition of mitochondrial damage-dependent corpus cavernosum smooth muscle cells apoptosis

Yuhang Xi

doi:10.1016/j.ejphar.2026.178949

Betulinic acid ameliorates cavernous nerve injury-induced erectile dysfunction through Nrf2/HO-1 pathway activation and inhibition of mitochondrial damage-dependent corpus cavernosum smooth muscle cells apoptosis

2026-05-09

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PRE

AI

Y

Yuhang Xi *

张绍华 (Shaohua Zhang)

X

Xiaojie Li

X

Xinjun Zhang

X

Xiangdong Xue

G

Guodong Hou

F

Feng Zhu *

DOI：10.1016/j.ejphar.2026.178949

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• BA improved corporal fibrosis, apoptosis, and ED in BCNI rats • BA blocked mitochondrial damage-dependent apoptosis in CCSMC via Nrf2/HO-1 activation • BA may provide a potential remedy for pRP-ED patients

Keywords:

Betulinic acid

erectile dysfunction

Nrf2/HO-1 pathway

mitochondrial damage

apoptosis

Betulinic acid ameliorates cavernous nerve injury-induced erectile dysfunction through Nrf2/HO-1 pathway activation and inhibition of mitochondrial damage-dependent corpus cavernosum smooth muscle cells apoptosis

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