Beyond Catheter Presence: Risk Factors for Progression to Bloodstream Infection During the COVID-19 Era - A Matched Case-Control Study

2026-07-09

Alessandra Gomes Chauvin *

André Luís Franco Cotia

Isabella Lemos Rosmino

Alexandra do Rosário Toniolo

Anderson P. Scorsato

Michael B. Edmond

DOI：10.1016/j.ajic.2026.07.003

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Abstract

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• Immunosuppression increased CLABSI risk over six-fold in catheterized patients • Each additional catheter day independently raised infection odds by3% • Klebsiella pneumoniae predominated; Pseudomonas and Candida rose during the pandemic • CLABSI risk did not increase in the pandemic period when infection controls were maintained • Carbapenem and quinolone resistance exceeded 16% and 32% among ESKAPE pathogens

Keywords:

Central line-associated bloodstream infection

risk factors

COVID-19 pandemic

antimicrobial resistance

Beyond Catheter Presence: Risk Factors for Progression to Bloodstream Infection During the COVID-19 Era - A Matched Case-Control Study

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