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Beyond static snapshots: Mitochondria in action
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DOI：10.1016/j.ceb.2024.102460.png)
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Abstract
En 中文
Mitochondria are dynamic organelles essential for cellular tion. Disruptions in these dynamics are linked to numerous diseases, including neurodegenerative disorders and cancer. Understanding these processes is vital for developing therapeutic strategies aimed at mitigating mitochondrial dysfunction. This review provides an overview of recent perspectives on mitochondrial dynamics, focusing on the need for live video microscopy imaging in order to fully understand mitochondrial phenotypes and pathology. Advanced imaging tools, such as machine learning-based segmentation and label-free microscopy approaches, have the potential to transform our ability to study mitochondrial dynamics in live cells.
Keywords:
FISSION
FUSION
MORPHOLOGY
TRANSPORT
HALLMARKS
DYNAMICS
DRP1
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