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Beyond the Barrier: Physiological Determinants of Nanoformulation Availability in the Aging Brain
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DOI：10.1016/j.arr.2026.103281.png)
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Abstract
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• Aging reshapes nanoparticle behavior beyond BBB permeability • Impaired glymphatic and vascular remodeling alter nanoparticle distribution • Chronic neuroinflammation increases clearance and reduces therapeutic retention • Nano-design must align with age-related physiological and microenvironmental changes • Chronopharmacological and stimuli-responsive strategies improve delivery efficacy
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