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Beyond the diagnostic threshold: paradigm shift in laboratory medicine from passive reaction to predictive capability
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DOI：10.3389/fmed.2026.1781957.png)
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Abstract
En 中文
Conventional laboratory medicine; which relies on diagnostic thresholds; operates within a reactive framework that is inherently constrained by its retrospective and static nature. This perspective article scrutinizes the paradigm shift in the field from a responsive to a predictive discipline. The transition is centered on integrating multi-omics data; continuous biosensing; and artificial intelligence to build predictive systems capable of early risk identification and individualized health guidance. The perspective article further investigates the conceptual underpinnings; implementation pathways; and related challenges—spanning technical; ethical; and health-system dimensions—of this evolving paradigm. This transformation not only redefines the scope of laboratory medicine but also positions it as a foundational component within precision medicine and prevention-focused public health frameworks.
Keywords:
artificial intelligence
precision medicine
multi-omics integration
laboratory medicine
diagnostic thresholds
predictive paradigm
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