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Bidirectional interactions between neuromodulatory systems and the cerebellum in brain function
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DOI：10.1016/j.neubiorev.2026.106716.png)
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Abstract
En 中文
• Both the cerebellum and neuromodulators regulate motor and cognitive behaviors. • Neuromodulators can powerfully tune cerebellar network and behavioral functions. • The cerebellum can, in turn, modulate key neuromodulatory centers. • Their multidimensional interactions likely play critical roles in brain function. • Future work should reveal how these interactions operate and why they matter.
Keywords:
GL
granular layer
PCL
Purkinje cell layer
ML
molecular layer
MF
mossy fiber
CF
climbing fiber
PC
Purkinje cell
GC
granule cell
PF
parallel fiber
GoC
Golgi cell
LuC
Lugaro cell
MLI
molecular layer interneuron
BG
Bergmann glial cell
UBC
unipolar brush cell
DCN
deep cerebellar nuclei
FN
fastigial nucleus
IPN
interposed nucleus
DN
dentate nucleus
VN
vestibular nucleus
5-HT
serotonin
NE
norepinephrine
ACh
acetylcholine
DA
dopamine
NRP
nucleus raphe pallidus
NRO
nucleus raphe obscurus
NRM
nucleus raphe magnus
DRN
dorsal raphe nuclei
LC
locus coeruleus
PPN
pedunculopontine tegmental nucleus
LDT
laterodorsal tegmental nucleus
VTA
ventral tegmental area
SNc
substantia nigra pars compacta
NAc
nucleus accumbens
mPFC
medial prefrontal cortex
5-HT1AR
serotonin 1A receptor
AR
adrenergic receptor
mAChR
muscarinic acetylcholine receptor
nAChR
nicotinic acetylcholine receptor
D1R
dopamine D1 receptor
STP
short-term potentiation
STD
short-term depression
LTP
long-term potentiation
LTD
long-term depression
Glu
glutamate
EPSC
excitatory postsynaptic current
TH
tyrosine hydroxylase
DISC
depolarization-induced slow current
VOR
vestibulo-ocular reflex
Sim
simplex lobule
FL/PFL
flocculus/paraflocculus
PM
paramedian lobule
Cop
copula pyramidis
cerebellum
serotonin
norepinephrine
dopamine
acetylcholine
projection
bidirectional regulation
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