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Bilirubin prevents hyperlipidaemic acute pancreatitis by inhibiting aryl hydrocarbon receptor-mediated acinar cell pyroptosis

delete2025-08-10
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PRE
AI
W
Wenjie Liang
H
Hanxiao Lu
B
Bo Wu
H
Hongnian Shen
X
Xiaoliang Dong
J
Jun Yang *
DOI：10.1111/bph.70168delete
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Abstract

Abstract

En 中文
Hyperlipidaemia-induced acute pancreatitis (HLAP) represents a specific subtype of acute pancreatitis (AP) characterised by elevated serum triglyceride levels. However, the precise pathophysiological mechanisms underlying HLAP remain unclear. Bilirubin, an essential haem metabolite, displays significant capabilities in neutralising oxidative stress and modulating inflammatory responses. Here, we investigate the role of bilirubin in mediating HLAP.
Keywords:
aryl hydrocarbon receptor
bilirubin
cell pyroptosis
hyperlipidaemic acute pancreatitis

Journal

British Journal of Pharmacology cover
British Journal of Pharmacology
IF:
7.7
Papers:
1.4W
Citations:
3.7W

Organization

J
Jiangnan University
Scholars:
3.9W
Papers: 2.7W
Citations: 4.7W
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