.png){kind=icon}
Return
Binding Studies on Modified Vancomycin
.png){kind=icon}
PRE
AI
DOI：10.1071/c96172.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Binding studies were carried out on a vancomycin derivative to examine its
potential bactericidal activity. Of particular interest was the effect of
dimethylation of the amino group at the N-terminus of vancomycin on the
binding ability of the antibiotic to bacterial cell-wall peptide analogues,
namely Ac-D-Ala-D-Ala and Ac2-L-Lys-D-Ala-D-Ala.
Reductive methylation was carried out with sodium cyanoborohydride and
formaldehyde, and the binding constants of the vancomycin derivative with the
peptides were measured by ultraviolet difference spectroscopy.
Journal
No journal information available
Organization
No organization information available
Cited Papers
No cited papers available