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Bio-electrosprayed Living Composite Matrix Implanted into Mouse Models
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DOI：10.1002/mabi.201100131.png)
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Abstract
En 中文
We show that composite de novo structures can be generated using bio-electrosprays. Mouse lung fibroblasts are bio-electrosprayed directly with a biopolymer to form cell-bearing matrices, which are viable even when implanted subcutaneously into murine hosts. Generated cell-bearing matrices are assessed in-vitro and found to undergo all expected cellular behaviour. Subsequent in-vivo studies demonstrate the implanted living matrices integrating as expected with the surrounding microenvironment. The in-vitro and in-vivo studies elucidate and validate the ability for either bio-electrosprays or cell electrospinning to form a desired living architecture for undergoing investigation for repairing, replacing and rejuvenating damaged and/or ageing tissues.
Keywords:
advanced biopolymers
bio-electrosprays
in vivo nterrogation/implantation
living three-dimensional matrices
mouse models
Journal
IF:
4.1
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3.9K
Citations:
9.3K